The function of transcription factor SCL in T cell development. [ 2003 - 2005 ]

Research Grant

Researchers: Dr David Izon (Principal investigator)

Brief description SCL is a gene which is abnormally expressed in a large percentage of human T cell leukaemias. Mouse models that increase SCL levels have demonstrated that T cell maturation is abnormally affected by SCL. Thus, providing a clue as to how T cell leukemias arise. By utilising recombinant DNA technology we are now able to control SCL levels in T cell maturation. We can either increase the level of SCL using pharmacological reagents or we can genetically remove SCL from maturing T cells. This double-edged approach will allow us to monitor the effects of SCL on maturing T cells with a precision that has never previously been achieved. Results from this approach will provide new insights into how T cell leukaemia develops and provide the foundation for new rational based treatments.

Funding Amount $AUD 504,750.00

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant