Transcriptional regulation of the Complement Receptor 2 gene (CR2/CD21) during B cell lineage committment [ 2004 - 2006 ]

Research Grant

Researchers: Dr Daniela Ulgiati (Principal investigator) ,  Prof Lawrence Abraham

Brief description The complement system is a very important pathway within the human immune system. One of the receptors within this system is complement receptor 2 or CR2. CR2 has not only been shown to be important within the inflammatory response and defence against microbes but is also important in normal generation of a B cell immune response . B cells not only produce antibodies against foreign organisms but in some cases dysfunction of the B cell can bring about autoimmunity by production of antibodies against self tissues and cells . How the CR2 gene turns on expression on different cells within the immune system is complex. The amount of receptor on the surface of antibody producing B cells has important implications to B cell biology. As CR2 expression is turned on at an important point within the antibody producing B cell and the levels of this receptor can influence B cell function, understanding how this gene is regulated is important.

Funding Amount $AUD 466,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant