grant

CSF-1 regulation of macrophage adhesion and motility and promotion of tumour invasion and metastasis [ 2008 - 2010 ]

Also known as: Growth factor regulation of motility in a type of white blood cell, macrophages, and its effects on cancer spread

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/513817]

Researchers: A/Pr Fiona Pixley (Principal investigator)

Brief description Macrophages, a type of white blood cell, infiltrate tumours and encourage tumour cells to metastasize. The mechanism involves secretion of a macrophage motility factor, CSF-1, by the tumour cells and secretion of a tumour cell motility factor by the macrophages to stimulate co-migration, invasion and metastasis. CSF-1 controls macrophage motility via the CSF-1 receptor. Dissection of receptor signalling pathways to macrophage motility will identify therapeutic targets to prevent tumour spread.

Funding Amount $AUD 323,453.08

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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Subjects
Biomedical and Clinical Sciences | CSF-1 signal transduction | Clinical Sciences | Diagnostic Radiography | breast cancer | cancer immunology | cell adhesion and motility | invasion and metastases | macrophage | microenvironment | tumour metastases | tyrosine kinase receptor |
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