Kallikrein proteases have key functional roles in peritoneal invasion and chemoresistance in epithelial ovarian cancer [ 2009 - 2011 ]

Research Grant

Researchers: Prof Judith Clements (Principal investigator) ,  Dr Ying Dong ,  Prof Dietmar Hutmacher ,  Prof Viktor Magdolen

Brief description Only 30% of ovarian cancer patients with advanced disease survive for 5 years. This is because the cancer quickly spreads into the abdominal cavity and often becomes resistant to chemotherapy. We aim to use a new 3D culture system, mouse models and novel inhibitors to study the roles of 4 kallikrein enzymes in these events. The outcomes from this study will lead to a better understanding of the role of kallikreins in ovarian cancer and may lead to new treatment approaches.

Funding Amount $AUD 815,541.34

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant