grant

Analysis of the functions of a novel class of ubiquitin E3 Ligases in TNF signalling in vivo [ 2010 - 2012 ]

Also known as: Analysis of novel regulators of TNF signalling

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/602516]

Researchers: Prof John Silke (Principal investigator) ,  Prof Henning Walczak

Brief description The aim of this project to discover the role of a novel ubiquitin ligase complex that regulates TNF superfamily signalling. It will increase understanding of the TNF pathway and improve our ability to manipulate it pharmacologically, or otherwise, in the large number of debilitating human diseases including Rheumatoid Arthritis and Crohn's disease that result from aberrant TNF signalling. Because of the role of TNF in tumorigenesis it may also contribute to novel anti-cancer treatments.

Funding Amount $AUD 568,861.04

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biochemistry and Cell Biology | Biological Sciences | Rheumatoid Arthritis | Signal Transduction | TNF Receptor | Ubiquitin E3 Ligases | apoptosis | arthritis, rheumatoid | autoimmunity | cell death | cytokine signalling | modulation of cytokine networks | molecular basis of disease |
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