Mechanistic characterisation of the epigenetic modifier Smchd1 [ 2016 - ]

Research Grant

Researchers: A/Pr Marnie Blewitt (Principal investigator) ,  A/Pr James Murphy ,  A/Pr Peter Czabotar ,  Dr Matthew Ritchie

Brief description FSHD is a progressive muscular dystrophy that currently has no treatment or cure. SMCHD1 is known to play an important role in FSHD, where its usual function in switching genes off is imperfect, contributing to disease. In this project we will determine how SMCHD1 switches genes off and what SMCHD1 looks like at the molecular level, so that we can elucidate how to boost SMCHD1 function for FSHD therapy.

Funding Amount $1,197,133.00

Funding Scheme Project Grants

Notes Standard Project Grant