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Full Record Details
Persistent URL
http://purl.org/net/epubs/work/65892
Record Status
Checked
Record Id
65892
Title
Composition and structure of mixed phospholipid supported bilayers formed by POPC and DPPC
Contributors
A Akesson
,
T Lind (STFC Rutherford Appleton Lab.)
,
N Ehrlich
,
D Stamou
,
H Wacklin
,
M Cardenas
Abstract
In this paper we present a systematic study of the morphology and composition of supported lipid bilayers (SLBs) formed by vesicle fusion using a wide variety of surface sensitive techniques that give information about the lateral as well as vertical structure and bilayer fluidity. SLBs of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) mixtures at five different bulk vesicle compositions were formed in such a way that the phase separation boundaries were crossed. For all compositions studied, the SLBs were systematically enriched with POPC compared to the nominal vesicle composition. Nevertheless, gel-fluid domain coexistence was observed for SLB compositions in which phase separation was expected based on the bulk phase diagram. The probable causes for the compositional difference in the SLBs are discussed in terms of the phase behaviour of the mixture and its effect on the membrane formation process by vesicle fusion.
Organisation
ISIS
,
ISIS-SURF
,
ISIS-INTER
,
STFC
Keywords
Funding Information
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Language
English (EN)
Type
Details
URI(s)
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Year
Journal Article
Soft Matter
8, no. 20 (2012): 5658-5665.
doi:10.1039/c2sm00013j
2012
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